Is it possible and safe to combine different vaccines? Some countries in the world already apply doses from two manufacturers
This week, pregnant and postpartum women in Rio de Janeiro who took the first dose of the Astrazeneca vaccine against Covid-19 were authorized by the state government to receive the second dose of a different immunizing agent, from Pfizer. It is a measure contrary to the one recommended by the Ministry of Health.
Then, the states of Rio and Ceará adopted the same measure.
The decision was taken by the municipality of Rio and endorsed by a committee of researchers, without the support of the Ministry of Health, which recommends that pregnant and postpartum women take the first dose of Astrazenca and wait up to 45 days after delivery to complete the vaccination schedule.
Now, those women who received the first dose of Astrazeneca, more than 12 weeks ago, will be able to mix the vaccines and take the second dose of Pfizer.
The decision brought up another discussion: is it possible and safe to combine different vaccines?
In Spain, a survey - not yet reviewed by other scientists - showed good results. Volunteers who took the first dose of Astrazeneca and, two weeks later, the second dose of Pfizer, had a significant increase in the production of antibodies that, in the laboratory, managed to inactivate the coronavirus.
In the UK, Oxford researchers who mixed the doses came to a similar conclusion. But they warned that trials have already shown an increased risk of side effects in this mixed immunization regimen.
None of the studies, neither Spanish nor English, involved pregnant women.
In the Philippines, another trial may be of interest to Brazil, as it combines CoronaVac with six other vaccines: Pfizer, Moderna, Janssen, Astrazeneca and Sputnik. But, is this enough for the national immunization plan to be changed, and allow combination?
Fast thousands around the world are getting mixed vaccines, as in Canada, Portugal and South Korea.
In Germany, Chancellor Angela Merkel took the first dose of Astrazeneca and the second of Moderna, another vaccine produced with MRNA technology, just like Pfizer.
In the United States, where 70% received the first dose and 46% are fully immunized, there is already a study to find out if it is advantageous to give a third booster dose with a different vaccine.
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